Panhypopituitarism

Hypopituitarism is a rare disorder in which your

pituitary gland

fails to produce one or more hormones, or doesn't produce enough hormones. Hypopituitarism is when you have a short supply (deficiency) of one or more of the pituitary hormones. These hormone deficiencies can affect any number of your body's routine functions, such as growth, blood pressure or reproduction. Symptoms typically vary, based on which hormone or hormones you are missing
Even after the proper regimen has been established, a patient with hypopituitarism requires lifelong medical follow-up.
Symptoms

Unsuccessful breastfeeding

common

Absence of period

  • Absence of period

or Irregular periods

common

Fatigue

common

Thinning or loss of hair anywhere

  • Pubic and armpit hair

common

Sudden hot sensation

or Excessively dry vagina

Depression

or Feeling moody

Inability to conceive a child

Decreased sexual desire

Short stature

Low blood pressure

Lack of concentration

Abnormally low blood sugar

Difficulty passing stool

Increased sensitivity to cold

Decreased breast size

Recent unexplained weight gain

High urine output

or Excessive thirst

Risk factors

Pituitary adenoma

Head injury

Head surgery

  • Pituitary resection

Radiation therapy

  • Head

Subarachnoid hemorrhage

Tuberculosis

Sarcoidosis

History of Hemophilia

or Sickle cell anemia

or Non-Hodgkin lymphoma

or Hodgkin lymphoma

or Leukemia

Diabetes mellitus

  • Type 2, Type 1

History of hemochromatosis

Treatment
The first step in treating hypopituitarism is often medication to help your hormone levels return to normal. This is usually called hormone replacement because the dosages are set to match the amounts that your body would produce if it didn't have a pituitary problem. You may need to take the medication for the rest of your life. In some cases, treatment of the condition causing hypopituitarism may lead to a complete or partial recovery of your body's ability to produce pituitary hormones. Hormone replacement medications may include: 1-Corticosteroids. These drugs, such as hydrocortisone (Cortef) or prednisone (Rayos), replace the adrenal hormones that aren't being produced because of an adrenocorticotropic hormone (ACTH) deficiency. You take them by mouth. 2-Levothyroxine (Levoxyl, Synthroid, others). This medication treats the low thyroid hormone levels (hypothyroidism) that a thyroid-stimulating hormone (TSH) deficiency can cause. 3-Sex hormones. These include testosterone in men and estrogen or a combination of estrogen and progesterone in women. Testosterone is administered either by injection or through the skin with a patch or a gel. Female hormone replacement can be administered with pills, gels or patches. 4-Growth hormone. Also called somatropin (Genotropin, Humatrope, others), growth hormone is administered through an injection beneath your skin. It promotes growth, which helps produce a more normal height in children. Adults with symptoms of growth hormone deficiency also may benefit from growth hormone replacement, but they won't grow taller. 5-Fertility hormones. If you've become infertile, gonadotropins can be administered by injection to stimulate ovulation in women and sperm production in men.
Recommended specialist

If you have Panhypopituitarism, then a visit to an endocrinologist is highly recommended.

Contact an

Endocrinologist

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