Herpetic whitlow doesn’t require treatment. The condition usually heals within a few weeks without medication, but a prescription antiviral drug can shorten the duration of an outbreak and can also help to lower the risk of transmitting the virus to other people. If a blister ruptures and an infection develops, your doctor can prescribe an antibiotic. You can treat herpetic whitlow at home by: 1-Taking a pain reliever — such as acetaminophen or ibuprofen — to help reduce pain and fever. 2-Applying a cold compress several times a day to help reduce swelling. 3-Cleaning the affected area daily and covering it with gauze.