Acute Tubular Necrosis

Acute tubular necrosis (ATN) is a medical condition involving the death of tubular epithelial cells that form the renal tubules of the kidneys. ATN presents with acute kidney injury (AKI) and is one of the most common causes of AKI.

Depending on the severity of the initial insult, time to renal recovery can often be prolonged and patients may require dialysis for months.
  • Symptoms
  • Decreased urine


    High blood pressure

    or Rapid heart rate

    or Dry mouth

    or Excessive thirst

    or Dehydration

    or Dark urine


    Feel like vomiting

    or Throwing up




    Enlarged feet or ankle

    or Swelling in lower leg

    or Enlarged thighs

    or Enlarged arms or hands

    or Swelling or lump in eyelid

    • Painless

    • Upper eyelid, Lower eyelid




    Poor appetite


    Muscle cramps

    Muscle pain

    Feeling sleepy

    A sudden and temporary alteration of muscle tone, movements or behavior

    or Fainting

  • Risk factors
  • Low blood pressure

    or Acute blood loss

    or Diarrhea

    or Burns

    or Heart failure

    Use of aminoglycoside

    or Use of Nonsteroidal Anti-Inflammatory Drug

  • Treatment
  • Intravenous furosemide or bumetanide in a single high dose (ie, 100-200 mg of furosemide) is commonly used, although little evidence indicates that it changes the course of ATN. The drug should be infused slowly because high doses can lead to hearing loss. If no response occurs, the treatment should be discontinued.
  • Recommended specialist
  • If you have Acute Tubular Necrosis, then a visit to a general internist is recommended.

    Contact a

    General internist

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