For a mild or moderate case of urticaria, the most common treatment is a non-sedating (does not cause drowsiness) antihistamine. Antihistamines relieve symptoms like itching. Antihistamines are also prescribed to treat chronic (lasting longer than six weeks) hives. When prescribed for chronic hives, you take this medicine every day to prevent hives from forming. There are many antihistamines on the market. Some make you drowsy, and some do not. Medicines that dermatologists prescribe to treat urticaria include: -Antihistamines. -Corticosteroids like prednisone. These are prescribed for short-term use due to side effects with long-term use. -Dapsone. This is an antibiotic that can also relieve redness and swelling -Omalizumab. This injectable medicine can help patients with chronic idiopathic urticaria (CIU), a type of hives that can last for months or even years. -Other medicines that fight inflammation. These treat redness and swelling. Ask your dermatologist about possible side effects (health problems that can result from the medicines).