Primary Biliary Cholangitis

Primary biliary cholangitis, previously called primary biliary cirrhosis, is a chronic disease in which the bile ducts in your liver are slowly destroyed. Chronic inflammation in the liver can lead to bile duct damage, irreversible scarring of liver tissue (cirrhosis) and eventually, liver failure.

As liver damage worsens, primary biliary cholangitis can cause serious health problems, including Liver scarring (cirrhosis).
  • Symptoms
  • Fatigue


    Itchy skin

    • Occurs or worsens at night

    • At palms and soles


    High levels of fats in blood


    Yellow eyes or skin

    or Dark urine

    or Poop with light color


    Easily get bone fractures


    Enlarged feet or ankle

    or Swollen belly

    or Swelling in lower leg


    Skin hyperpigmentation


    Yellow papule(s) or nodule(s) on the skin

    Abdominal pain

    • In the upper right region, Located in middle upper region

    Skin rash and redness

    • At chest, At back, At abdomen, At upper extremity except hand, At legs not feet

    • Painless

    • At face, At neck, At scalp, At hands, At feet

    or Swollen blood vessels on the skin that looks like a spiders web

    • Over upper body

    Weight loss

    or Loss of muscle mass

    or Poor appetite


    • Steatorrhea

  • Risk factors
  • Sjogren's syndrome

    Any thyroid disease

    or Hashimoto thyroiditis

    or Thick and hard skin

    or Rheumatoid arthritis

  • Treatment
  • There's no cure for primary biliary cholangitis, but medications are available to help slow the progression of the disease and prevent complications. Options include Ursodeoxycholic acid (UDCA). This medication, also known as ursodiol (Actigall, Urso), is commonly used first.
  • Recommended specialist
  • If you have Primary Biliary Cholangitis, then a visit to a gastroenterologist is highly recommended.

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