Is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and interferes with their normal function. Amyloid isn't normally found in the body, but it can be formed from several different types of protein. Amyloid is produced in your bone marrow and can be deposited in any tissue or organ.

Amyloidosis is a serious health problem that can lead to life-threatening organ failure.
  • Symptoms
  • Fatigue


    Swelling or lump in eyelid

    or Enlarged feet or ankle

    or Swelling in lower leg

    • In both lower legs

    or Urine with bubbles unrelated to speed of urination or bladder fullness


    Abdominal mass

    • Right upper quadrant

    • Located in middle upper region


    Swollen neck vein

    or Difficulty breathing

    • Occurs or worsens with exertion

    • During sleep, Occurs when lying flat


    Poor appetite


    Unexplained skin injury

    or Bleeding easily or difficulty controlling bleeding


    Weight loss


    Waxy skin


    Throwing up

    • Blood in vomit, Dark brown liquid

    or Black stool

    or Bleeding from anus


    Irregular heartbeat

    or Fainting

    or Dizziness


    Muscle pain


    Swollen belly

    Tongue with wavy edges

    or Enlarged tongue without inflammation or swelling

    Fat in stool

    A burning feeling in thigh

    or A burning feeling in arms

    or Gradual lower limb weakness

    or Numbness or tingling in shoulders arms or hands

    or A burning feeling in legs or feet

    or Numbness or tingling in legs, feet, or buttocks

    or Gradual upper limb weakness

    Feel like vomiting

    or Abdominal bloating

    or Abdominal pain

    • Nonspecific, non-focal

    Numbness or tingling in hand

    • Palmar aspect

    • Radiates to fingers

    • Occurs or worsens with activities that involve sustained flexing or extending the wrist

    • Occurs or worsens at night

    or Pain in arms

    or Weakness of hand

    Decreased urine

    Alternation between diarrhea and constipation

    Noise while breathing

    or Swallowing difficulties

    or Strained voice

    Jaw pain

    Enlarged shoulder

    • Both shoulders

    Dry eyes

    or Blurred vision

    or Difficulty hearing

    • Both ears

  • Risk factors
  • Multiple myeloma

    or Inflammation of the colon

    • Crohns disease

    or Rheumatoid arthritis

    Family history of amyloidosis

    History of alzheimer disease

    Kidney failure or on dialysis

  • Treatment
  • There's no cure for amyloidosis. But treatment can help manage signs and symptoms and limit further production of amyloid protein.
  • Recommended specialist
  • If you have Amyloidosis, then a visit to a general internist is recommended.

    Contact a

    General internist

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