Amyloidosis

Is a rare disease that occurs when an abnormal protein, called amyloid, builds up in your organs and interferes with their normal function. Amyloid isn't normally found in the body, but it can be formed from several different types of protein. Amyloid is produced in your bone marrow and can be deposited in any tissue or organ.
Amyloidosis is a serious health problem that can lead to life-threatening organ failure.
Symptoms

Fatigue

common

Swelling or lump in eyelid

  • Both sides, Both eyes

  • Painless

or Enlarged feet or ankle

  • In both feet or ankles

or Swelling in lower leg

  • In both lower legs

or Urine with bubbles unrelated to speed of urination or bladder fullness

common

Abdominal mass

  • Right upper quadrant

  • Located in middle upper region

common

Swollen neck vein

or Difficulty breathing

  • Occurs or worsens with exertion

  • During sleep, Occurs when lying flat

common

Poor appetite

common

Unexplained skin injury

or Bleeding easily or difficulty controlling bleeding

common

Weight loss

common

Waxy skin

common

Throwing up

  • Blood in vomit, Dark brown liquid

or Black stool

or Bleeding from anus

common

Irregular heartbeat

or Fainting

or Dizziness

common

Muscle pain

common

Swollen belly

Tongue with wavy edges

or Enlarged tongue without inflammation or swelling

Fat in stool

A burning feeling in thigh

or A burning feeling in arms

or Gradual lower limb weakness

or Numbness or tingling in shoulders arms or hands

or A burning feeling in legs or feet

or Numbness or tingling in legs, feet, or buttocks

or Gradual upper limb weakness

Feel like vomiting

or Abdominal bloating

or Abdominal pain

  • Nonspecific, non-focal

Numbness or tingling in hand

  • Palmar aspect

  • Radiates to fingers

  • Occurs or worsens with activities that involve sustained flexing or extending the wrist

  • Occurs or worsens at night

or Pain in arms

or Weakness of hand

Decreased urine

Alternation between diarrhea and constipation

Noise while breathing

or Swallowing difficulties

or Strained voice

Jaw pain

Enlarged shoulder

  • Both shoulders

Dry eyes

or Blurred vision

or Difficulty hearing

  • Both ears

Risk factors

Multiple myeloma

or Inflammation of the colon

  • Crohns disease

or Rheumatoid arthritis

Family history of amyloidosis

History of alzheimer disease

Kidney failure or on dialysis

Treatment
There's no cure for amyloidosis. But treatment can help manage signs and symptoms and limit further production of amyloid protein.
Recommended specialist

If you have Amyloidosis, then a visit to a general internist is recommended.

Contact a

General internist

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