Acute Interstitial Nephritis

Acute interstitial nephritis (AIN) is a sudden condition characterized by the inflammation of the kidneys. The main functions of your kidneys are to filter your blood and to get rid of waste from your body. The kidney tubules reabsorb water and important organic substances from the filtered blood and secrete substances you don’t need into your urine for removal from your body. Swelling of these tubules can cause a number of kidney symptoms that range from mild to severe.

Acute interstitial nephritis may be more severe and more likely to lead to long-term or permanent kidney damage in older people.
  • Symptoms
  • Fever

    • Greater than or equal to 38°C (100.4°F), Less than 38°C (100. 4°F)


    Skin rash and redness


    Pus in urine

    or Blood in urine


    Back pain

    • Localized

    • Lower


    Joint pain


    Abdominal pain

    • Flank pain


  • Risk factors
  • Use of Proton-Pump Inhibitors

    or Use of penicillin

    or Use of cephalosporin

    or Use of trimethoprim sulfamethoxazole

    or Use of sulfonamide

    or Use of diuretics

    or Rifampin antibiotic

    or Use of Nonsteroidal Anti-Inflammatory Drug

    Infection in any part of urinary system

    or Poor genital hygiene

    Systemic Lupus Erythematosus (SLE)

    or Sarcoidosis

    Uncircumcised penis

    Recent upper respiratory tract infection

  • Treatment
  • When AIN is caused by a drug allergy, the only treatment needed may be drug removal. Other cases of AIN can be treated with anti-inflammatory medications. Quick treatment often leads to a full recovery.
  • Recommended specialist
  • If you have Acute Interstitial Nephritis, then visit a general internist as soon as possible.

    Contact a

    General internist

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